Ordering Recommendation

Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Patient must be fasting for 12-15 hours prior to collection.

Collect

Serum separator tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube and freeze immediately. (Min: 0.8 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Heparinized plasma. Vitreous or I.V. fluids. Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 2 months (avoid repeated freeze/thaw cycles)

Methodology

Quantitative Chemiluminescent Immunoassay (CLIA)/Quantitative Chemiluminescent Immunoassay (CLIA)

Performed

Tue, Thu

Reported

1-6 days

Reference Interval

Test Number
Components
Reference Interval
  Insulin, Fasting 3-25 µIU/mL
  Proinsulin, Intact
Age
pmol/L
0-17 year Not established
18 years and older Less than or equal to 7.2

  Proinsulin, Intact/Insulin Ratio Calc
Age
Ratio (%)
0-17 years Not established
18 years and older 0.6 - 15.8

Interpretive Data

Insulin, fasting: This test reacts on a nearly equimolar basis with the analogs insulin aspart, insulin glargine, and insulin lispro. Insulin detemir exhibits approximately 50 percent cross-reactivity. Test reactivity with insulin glulisine is negligible (less than 3 percent). To convert to pmol/L, multiply IU/mL by 6.0.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

84206; 83525

Components

Component Test Code* Component Chart Name LOINC
0070063 Insulin, Fasting 27873-9
0070112 Proinsulin, Intact 10451-3
0070257 Proinsulin, Intact/Insulin Ratio Calc 45338-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Insulin proinsulin
  • Insulin proinsulin ratio
  • Intact proinsulin
  • Proinsulin
  • Proinsulin, Intact
Proinsulin, Intact/Insulin Ratio